FEATURES

FAMILY

N-acetylmuramoyl-L-alanine amidase 2 family

DESCRIPTION

Also known as PGRP3_HUMAN, PGLYRP3, PGRPIA. Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PGLYRP3

Mutations

Mutation(s) distribution

Mutations table