FEATURES

FAMILY

DESCRIPTION

Also known as ROBO3_HUMAN, ROBO3. Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity). In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing (PubMed:15105459). Probably interacts with SLIT2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ROBO3

Mutations

Mutation(s) distribution

Mutations table