FEATURES

FAMILY

DESCRIPTION

Also known as LRRC7_HUMAN, LRRC7, KIAA1365, LAP1. Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. Interacts with CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2 (PubMed:11729199). Interacts with CAMK2A (PubMed:28130356).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LRRC7

Leucine-rich repeat-containing protein 7

LRRC7

Molecular Synopsis