FEATURES

FAMILY

DESCRIPTION

Also known as LMTK3_HUMAN, LMTK3, KIAA1883, TYKLM3. Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity). Interacts with ESR1 (PubMed:21602804). Interacts with AP-2 complex subunit alpha (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LMTK3

Serine/threonine-protein kinase LMTK3

LMTK3

Molecular Synopsis