FEATURES

FAMILY

DESCRIPTION

Also known as GSDMA_HUMAN, GSDMA, GSDM, GSDM1. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death., Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:17471240, PubMed:27281216). Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:27281216). Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4, 5)-bisphosphate (PubMed:27281216). The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (PubMed:27281216). Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane.

Also known as GSDMA_HUMAN, GSDMA, GSDM, GSDM1. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to me ...

EXTERNAL LINKS

GSDMA

Gasdermin-A

GSDMA

Molecular Synopsis