FEATURES

DESCRIPTION

Also known as NACC1_HUMAN, NACC1, BTBD14B, NAC1. Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NACC1

Nucleus accumbens-associated protein 1

NACC1

Molecular Synopsis