FEATURES

FAMILY

Classic translation factor GTPase family

DESCRIPTION

Also known as EFGM_HUMAN, GFM1, EFG, EFG1, GFM. Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.

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EXTERNAL LINKS

GFM1

Elongation factor G, mitochondrial

ligandability Mutations

GFM1

Molecular Synopsis