FEATURES

FAMILY

DESCRIPTION

Also known as ERBIN_HUMAN, ERBIN, ERBB2IP, KIAA1225, LAP2. Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). Interacts with ERBB2, BPAG1 and ITGB4 (PubMed:10878805, PubMed:11375975, PubMed:12444095). May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin (PubMed:11821434). Interacts (via C-terminus) with DST Isoform 3 (via N-terminus) (PubMed:11375975). Interacts with NOD2 (via CARD domain) (PubMed:16203728).

Also known as ERBIN_HUMAN, ERBIN, ERBB2IP, KIAA1225, LAP2. Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribut ...

EXTERNAL LINKS

ERBIN

Erbin

ERBIN

Molecular Synopsis