FEATURES

DESCRIPTION

Also known as PKHF1_HUMAN, PLEKHF1, APPD, LAPF, ZFYVE15. May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PLEKHF1

Pleckstrin homology domain-containing family F member 1

PLEKHF1

Molecular Synopsis