FEATURES

FAMILY

DESCRIPTION

Also known as CDC61_SACS2, cdc6-1. Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds to DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Inhibits the binding of the MCM helicase to the origin DNA and strongly inhibits its DNA helicase activity. Also regulates the DNA polymerase and the nuclease activities of PolB1. Stimulates the DNA-binding activity of Cdc6-3. Monomer. Interacts with Cdc6-3, MCM and PolB1.

EXTERNAL LINKS

uniprot
enzyme classification

cdc6-1

ORC1-type DNA replication protein 1

cdc6-1

Molecular Synopsis