FEATURES

FAMILY

DESCRIPTION

Also known as NEUR1_HUMAN, NEU1, NANH. Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. Interacts with cathepsin A (protective protein), beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NEU1

Sialidase-1

NEU1

Molecular Synopsis