FEATURES

FAMILY

DESCRIPTION

Also known as SMAD5_HUMAN, SMAD5, MADH5. Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. Interacts with TMEM119 (By similarity). Interacts with ZNF8 (PubMed:12370310). Interacts with RANBP3L (PubMed:25755279).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SMAD5

Mothers against decapentaplegic homolog 5

Mutations

Mutation(s) distribution

Mutations table

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