FEATURES

DESCRIPTION

Also known as APBA2_HUMAN, APBA2, MINT2, X11L. Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid-beta protein, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of NECAB3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

APBA2

Amyloid-beta A4 precursor protein-binding family A member 2

APBA2

Molecular Synopsis