FEATURES

FAMILY

DESCRIPTION

Also known as GDIR3_HUMAN, ARHGDIG. Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ARHGDIG

Rho GDP-dissociation inhibitor 3

ARHGDIG

Molecular Synopsis