FEATURES

FAMILY

DESCRIPTION

Also known as VRK1_HUMAN, VRK1. Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.

EXTERNAL LINKS

VRK1

Serine/threonine-protein kinase VRK1

3D Viewer

2KTY_A

CAVITIES

STRUCTURE SETTINGS

LIGANDS

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