FEATURES

FAMILY

DESCRIPTION

Also known as GORS2_MOUSE, Gorasp2. Plays a role in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:28617811). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (By similarity). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (PubMed:28617811). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity). Homodimer. Homooligomer. ER stress induces phosphorylation-dependent monomerization (By similarity). Interacts with BLZF1/Golgin 45 (PubMed:11739401, PubMed:28049725). Identified in a complex with RAB2 and GORASP2 (PubMed:11739401). Interacts with JAM2 and JAM3 (PubMed:28617811). Interacts with members of the p24 cargo receptors. Interacts with CNIH and the cytoplasmic domain of transmembrane TGFA, prior its transit in the trans-Golgi. Interacts with KCTD5 (By similarity). Interacts with TMED2 and TMED3 (By similarity). Interacts with SEC16A in response to ER stress (By similarity). Interacts (via PDZ GRASP-type 1 domain) with core-glycosylated CFTR in response to ER stress (By similarity).

EXTERNAL LINKS

Gorasp2

Mutations

Mutation(s) distribution

Mutations table