FEATURES

FAMILY

DESCRIPTION

Also known as RB27B_MOUSE, Rab27b. Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A. Interacts (GDP-bound form preferentially) with DENND10 (By similarity).

EXTERNAL LINKS

Rab27b

Mutations

Mutation(s) distribution

Mutations table