FEATURES

DESCRIPTION

Also known as PCD15_MOUSE, Pcdh15. Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. Antiparallel heterodimer with CDH23 (PubMed:23135401, PubMed:17805295). Found in a complex with TMIE and LHFPL5 (PubMed:25467981). Interacts with LHFPL5/TMHS; this interaction is required for efficient localization to hair bundles (PubMed:23217710). Interacts with MYO7A (PubMed:16481439). Interacts with USH1G; this interaction may recruit USH1G to the plasma membrane (PubMed:21436032). Interacts with TOMT (PubMed:28504928). Isoforms CD1 and CD3 interact with TMC1 (via N-terminus) and TMC2 (via N-terminus) (PubMed:25114259).

EXTERNAL LINKS

Pcdh15

Protocadherin-15

Pcdh15

Molecular Synopsis