FEATURES

FAMILY

DESCRIPTION

Also known as PAIP2_HUMAN, PAIP2, PAIP2A. Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PAIP2

Polyadenylate-binding protein-interacting protein 2

PAIP2

Molecular Synopsis