FEATURES

FAMILY

DESCRIPTION

Also known as ECSIT_HUMAN, ECSIT. Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity)., Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9 (By similarity). Interacts with NDUFAF1 (PubMed:17344420). Interacts with ACAD9 (PubMed:20816094). Interacts with TRIM59 (By similarity).

EXTERNAL LINKS

ECSIT

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

ECSIT

Molecular Synopsis