FEATURES

FAMILY

DESCRIPTION

Also known as LZTS2_HUMAN, LZTS2, KIAA1813, LAPSER1. Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LZTS2

Leucine zipper putative tumor suppressor 2

LZTS2

Molecular Synopsis