FEATURES

DESCRIPTION

Also known as RHG09_HUMAN, ARHGAP9. GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3, 4, 5-trisphosphate, followed by phosphatidylinositol 3, 4-bisphosphate and phosphatidylinositol 4, 5-bisphosphate. Interacts with FASLG.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ARHGAP9

Mutations

Mutation(s) distribution

Mutations table