FEATURES

FAMILY

DESCRIPTION

Also known as ESYT1_HUMAN, ESYT1, FAM62A, KIAA0747, MBC2. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Interacts (phosphorylated form) with SLC2A4 (By similarity). Interacts with ESYT2 and ESYT3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ESYT1

Extended synaptotagmin-1

ESYT1

Molecular Synopsis