FEATURES

DESCRIPTION

Also known as DIDO1_HUMAN, DIDO1, C20orf158, DATF1, KIAA0333. Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development., Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. Interacts specifically (via PHD-type zinc finger) with histone H3 that is trimethylated at 'Lys-4' (H3K4me3), histone phosphorylation at 'Thr-3' or 'Thr-6' disrupts this binding and promotes translocation of DIDO1 from chromatin to the mitotic spindle during mitosis.

Also known as DIDO1_HUMAN, DIDO1, C20orf158, DATF1, KIAA0333. Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryoni ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DIDO1

Death-inducer obliterator 1

DIDO1

Molecular Synopsis