FEATURES

FAMILY

DESCRIPTION

Also known as DPH7_HUMAN, DPH7, C9orf112, WDR85. Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Interacts with INCA1.

Also known as DPH7_HUMAN, DPH7, C9orf112, WDR85. Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modificati ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DPH7

Diphthine methyltransferase

DPH7

Molecular Synopsis