FEATURES

DESCRIPTION

Also known as SPON2_HUMAN, SPON2, DIL1. Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). Monomer. Interacts with integrin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SPON2

Spondin-2

SPON2

Molecular Synopsis