FEATURES

FAMILY

DESCRIPTION

Also known as NTM1A_HUMAN, NTMT1, C9orf32, METTL11A, NRMT, NRMT1. Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Also known as NTM1A_HUMAN, NTMT1, C9orf32, METTL11A, NRMT, NRMT1. Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly ...

EXTERNAL LINKS

NTMT1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

NTMT1

Molecular Synopsis