FEATURES

DESCRIPTION

Also known as MAD3_HUMAN, MXD3, BHLHC13, MAD3. Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MXD3

Max dimerization protein 3

MXD3

Molecular Synopsis