FEATURES

FAMILY

DESCRIPTION

Also known as KATL1_HUMAN, KATNAL1. Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed:26929214). Interacts with KATNB1 and KATNBL1.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

KATNAL1

Katanin p60 ATPase-containing subunit A-like 1

ligandability Mutations

KATNAL1

Molecular Synopsis