FEATURES

FAMILY

DESCRIPTION

Also known as TTLL2_HUMAN, TTLL2, C6orf104. Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (By similarity). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (By similarity). Probably involved in the side-chain initiation step of the polyglutamylation reaction rather than the elongation step (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TTLL2

Probable tubulin polyglutamylase TTLL2

TTLL2

Molecular Synopsis