FEATURES

FAMILY

DESCRIPTION

Also known as NPL_HUMAN, NPL, C1orf13. Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity). Experiments show the true substrate is aceneuramate (linearized Neu5Ac) (PubMed:33895133). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NPL

N-acetylneuraminate lyase

NPL

Molecular Synopsis