FEATURES

FAMILY

DESCRIPTION

Also known as ITPA_HUMAN, ITPA, C20orf37. Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ITPA

Inosine triphosphate pyrophosphatase

ITPA

Molecular Synopsis