FEATURES

FAMILY

DESCRIPTION

Also known as B3GN5_HUMAN, B3GNT5. Beta-1, 3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

B3GNT5

Lactosylceramide 1, 3-N-acetyl-beta-D-glucosaminyltransferase

B3GNT5

Molecular Synopsis