FEATURES

FAMILY

DESCRIPTION

Also known as ANO3_HUMAN, ANO3, C11orf25, TMEM16C. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:21984732). Interacts with KCNT1/Slack.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ANO3

Anoctamin-3

ANO3

Molecular Synopsis