FEATURES

FAMILY

DESCRIPTION

Also known as CELF4_HUMAN, CELF4, BRUNOL4. RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CELF4

CUGBP Elav-like family member 4

CELF4

Molecular Synopsis