FEATURES

FAMILY

SIGLEC (sialic acid binding Ig-like lectin) family

DESCRIPTION

Also known as SN_HUMAN, SIGLEC1, SN. Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2, 3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SIGLEC1

Sialoadhesin

SIGLEC1

Molecular Synopsis