FEATURES

FAMILY

DESCRIPTION

Also known as TRIM7_HUMAN, TRIM7, GNIP, RNF90. E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon (By similarity). Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128)., (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination. Forms homodimers, and heterodimers with GNIP2 (PubMed:14984203, PubMed:25851810). Interacts with GYG (PubMed:11916970, PubMed:14984203). Interacts with RNF187 (via C-terminus) (PubMed:25851810).

EXTERNAL LINKS

TRIM7

E3 ubiquitin-protein ligase TRIM7

TRIM7

Molecular Synopsis