FEATURES

FAMILY

DESCRIPTION

Also known as PHAR1_HUMAN, PHACTR1, KIAA1733, RPEL1. Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). Interacts (via RPEL repeats) with ACTA1 and PPP1CA; ACTA1 and PPP1CA compete for the same binding site.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PHACTR1

Mutations

Mutation(s) distribution

Mutations table