FEATURES

DESCRIPTION

Also known as CEP44_HUMAN, CEP44, KIAA1712. Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall (PubMed:32060285). Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome (PubMed:31974111). Interacts with CROCC (PubMed:31974111). Interacts with POC1B; the interaction is direct and recruits POC1B to centriolar microtubules (PubMed:32060285). Binds to centriolar microtubules (PubMed:32060285).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CEP44

Centrosomal protein of 44 kDa

CEP44

Molecular Synopsis