FEATURES

FAMILY

DESCRIPTION

Also known as EIF3H_ARATH, TIF3H1. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Regulates translation initiation of specific 5' mRNAs harboring multiple upstream open reading frames (uORFs) in their 5' leader sequence (e.g. BETA-OHASE 2 and LHY) (PubMed:15548739, PubMed:17439654, PubMed:23524850). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. Interacts directly with TIF3A1, TIF3B1, TIF3C1, TIF3E1 and TIF3F1 (PubMed:15548739, PubMed:20444226). Associates with the CSN (COP9 signalosome) complex. Binds to CSN1, CSN7 and CSN8 (PubMed:15548739). Interacts with ATPK1 (PubMed:23524850).

EXTERNAL LINKS

TIF3H1

Eukaryotic translation initiation factor 3 subunit H

TIF3H1

Molecular Synopsis