FEATURES

FAMILY

DESCRIPTION

Also known as VM3V1_CROAT, VM3V1. Zinc metalloprotease that has fibrinogenolytic and hemorrhagic activities. It induces apoptosis in vascular endothelial cells (VEC), without degrading extracellular matrix (it cannot cleave collagen) or inhibiting adhesion of VEC. VAP1-induced apoptosis is inhibited by antibodies for integrin alpha-3, alpha-6, beta-1 and CD9. Apoptosis is accompanied by severe cell fragmentation, which is controlled by caspases. Homodimer; disulfide-linked.

EXTERNAL LINKS

uniprot
enzyme classification

VM3V1

Zinc metalloproteinase-disintegrin-like VAP1

VM3V1

Molecular Synopsis