FEATURES

DESCRIPTION

Also known as ARHGB_RAT, Arhgef11. May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth (By similarity). Interacts with RHOA, GNA13 and SLC1A6. Interacts with GNA12, PLXNB1 and PLXNB2 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus) (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Arhgef11

Rho guanine nucleotide exchange factor 11

Arhgef11

Molecular Synopsis