FEATURES

DESCRIPTION

Also known as RNG1A_ARATH, RING1A, RF434. Putative E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119ub), thereby playing a central role in histone code and gene regulation., As part of the PRC1-like complex, repress class I KNOX gene expression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Homodimer or heterodimer with RING1B. Interacts with CLF. Component of the PRC1-like complex, at least composed of RING1A, RING1B and LHP1.

EXTERNAL LINKS

uniprot
enzyme classification

RING1A

Putative E3 ubiquitin-protein ligase RING1a

RING1A

Molecular Synopsis