FEATURES

FAMILY

DESCRIPTION

Also known as ELOV4_HUMAN, ELOVL4. Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. Oligomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ELOVL4

Elongation of very long chain fatty acids protein 4

ELOVL4

Molecular Synopsis