FEATURES

FAMILY

krueppel C2H2-type zinc-finger protein family

DESCRIPTION

Also known as PEG3_HUMAN, PEG3, KIAA0287, ZSCAN24. Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PEG3

Mutations

Mutation(s) distribution

Mutations table