FEATURES

DESCRIPTION

Also known as WWTR1_HUMAN, WWTR1, TAZ. Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). Binds to SLC9A3R2 via the PDZ motif at the plasma membrane (By similarity). Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP (By similarity). Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4 (PubMed:18568018). Interacts with MED15 (PubMed:18568018). Interacts with PAX8 and NKX2-1 (PubMed:19010321). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (PubMed:19324877). Interacts (via WW domain) with PALS1 (PubMed:21145499). Interacts with LATS1 (By similarity). Interacts with YAP1 (when phosphorylated at 'Ser-127') (By similarity). Interacts (via WW domain) with PRRG4 (via cytoplasmic domain) (PubMed:23873930).

EXTERNAL LINKS

WWTR1

Mutations

Mutation(s) distribution

Mutations table