FEATURES

FAMILY

DESCRIPTION

Also known as MIS12_HUMAN, MIS12. Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108). Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MIS12

Protein MIS12 homolog

MIS12

Molecular Synopsis