FEATURES

FAMILY

DESCRIPTION

Also known as GBRL1_HUMAN, GABARAPL1, GEC1. Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). Interacts with ATG13, OPRK1, RB1CC1 and ULK1 (PubMed:16431922, PubMed:23043107). Interacts with TP53INP1 and TP53INP2 (PubMed:22470510). Directly interacts with SQSTM1 (PubMed:17580304). Interacts with ATG3, ATG7 and MAP15. Interacts with TECPR2 (PubMed:20562859). Interacts with TBC1D5 (PubMed:22354992). Interacts with MAPK15 (PubMed:22948227). Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV and TRIM21 (PubMed:26347139). Interacts with WDFY3 (PubMed:24668264). Interacts with the reticulophagy receptor TEX264 (PubMed:31006538, PubMed:31006537). Interacts with UBA5 (PubMed:26929408). Interacts with KBTBD6 AND KBTBD7; the interaction is direct (PubMed:25684205).

EXTERNAL LINKS

GABARAPL1

Mutations

Mutation(s) distribution

Mutations table