FEATURES

FAMILY

DESCRIPTION

Also known as ATG10_HUMAN, ATG10, APG10L. E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity). Interacts with IRGM.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ATG10

Ubiquitin-like-conjugating enzyme ATG10

ATG10

Molecular Synopsis