FEATURES

FAMILY

DESCRIPTION

Also known as SEM6A_HUMAN, SEMA6A, KIAA1368, SEMAQ. Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation., (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. Active as a homodimer or oligomer (By similarity). The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer (By similarity). Interacts with EVL (PubMed:10993894).

EXTERNAL LINKS

SEMA6A

Semaphorin-6A

SEMA6A

Molecular Synopsis